Yes, it supports Ultra HD (3840 x 2160) output via both HDMI and 6G-SDI, allowing you to see four full HD views on a single 4K monitor in 2x2 mode.
Yes, the MultiView 16 features full resynchronization on every input, allowing you to mix SD, HD, and Ultra HD formats and frame rates simultaneously.
It can be controlled via the included Blackmagic MultiView software utility over Ethernet, or via the front panel hardware buttons and rotary knob.